sma4dBioGRID Interaction 297491 Between SEMA4D And PTPRC. sema domain, immunoglobulin domain (), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4DSema4D, a member of the immune semaphorin family, plays crucial roles in the immune regulation, bone resorption and nervous system. It is also involved in angiogenesis and tumour