sma4dSema4D, a member of the immune semaphorin family, plays crucial roles in the immune regulation, bone resorption and nervous system. It is also involved in angiogenesis and tumourBioGRID Interaction 297491 Between SEMA4D And PTPRC. sema domain, immunoglobulin domain (), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D