Antibody Blockade of Semaphorin 4D Promotes Immune

sma4dSMAD4 is the only common SMAD in TGF-β snaling that usually impedes immune cell activation in the tumor microenvironment. However, we demonstrated here thatSema4D, a member of the immune semaphorin family, plays crucial roles in the immune regulation, bone resorption and nervous system. It is also involved in angiogenesis and tumour